It’s 101 pathways, tips, and studies surrounding all things CBD and anxiety.

CARMEL, CA, February 26, 2023 /24-7PressRelease/ — It’s difficult to separate hype from real research around any supplement but CBD isolate is definitely fraught with its share of buzz and by default, promises. This is especially true around the subject of anxiety.

What does research really show for CBD’s effects on the pathways directly tied to anxiety?

– GABA – the target of benzos
– Serotonin – the target of SSRIs
– Cortisol – our stress pathway

There is real research…NIH research across these key pathways for anxiety and many other topics including brain inflammation, gut function, vagus nerve, prior trauma/infection, and much more.

Most interesting is the comparison between CBD and THC, alcohol, benzos, or SSRIs on specific pathways and how tolerance, or the body’s pushback response, is the key difference that very few people realize may be THE issue.

Where most anxiety tools are agonists or antagonists…meaning, they push a key pathway up or down in one direction, CBD supports the endocannabinoid system which is tasked with balancing every other pathway.

This amounts to a “feedback” effect when a key pathway is exhausted (say GABA or serotonin) or too strong (cortisol, our stress hormone for example) which avoids the tolerance pushback from the brain and body. The result of this “balancing” aid from CBD isolate has profound effects across multiple dynamics driving states of anxiety.

A final note looks at how early trauma, stress, and infection can dysregulate every facet tied to anxiety later in life with tools to “edit” these changes out of the immune system and epigenome, a layer of instruction that determines what genes are expressed.

Learn more on the 101 tips, pathways, and studies surrounding CBD and anxiety here:

IndigoNaturals aims to make CBD straight forward, easy to understand, and affordable to more people everywhere. Educating people on every facet of cannabidiol is part of their mission to help the most people feel their very best. Learn more at

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